64-bit computing, from operating systems to creative software.
I've used Microsoft Windows Vista Ultimate 64-bit for over a month now and I'm quite comfortable with it. Aside from the GUI, there's little change from Windows XP, but it supports DirectX 10. Just one Blue Screen so far.
Adobe Creative Suite 4 will support 64-bit operating systems on Windows, but remain 32-bit only on Mac; full 64-bit Mac support waits until Creative Suite 5. Adobe says it's giving customers this guidance on Photoshop as early as possible.